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An ACC showdown is set to take center stage on Friday when the Boston College Eagles host the Louisville Cardinals. Both teams enter Friday's matchup with a 4-3 record. Louisville has won two of the past three meetings against Boston College, including a 56-28 victory at home in 2023. Both squads are also 2-4 against the spread this season and on four game ATS losing streaks. Louisville will go forward without receiver Caullin Lacy, who decided this week to opt out of the remainder of the season. 

Kickoff from BC Alumni Stadium is set for 7:30 p.m. ET. After opening at -6.5, the Cardinals are now 7.5-point favorites, according to the latest Louisville vs. Boston College odds via SportsLine consensus, while the over/under for total points scored is 53.5, up one point from the opener. Before making any Boston College vs. Louisville picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college football spread picks, and it is a sizzling 14-7 on all top-rated picks over the past four weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has set its sights on Louisville vs. Boston College. You can head to SportsLine now to see its picks. Here are several college football betting lines for Boston College vs. Louisville:

  • Louisville vs. Boston College spread: Louisville -7.5
  • Louisville vs. Boston College over/under: 53.5 points
  • Louisville vs. Boston College money line: Louisville -289, Boston College +230
  • Louisville vs. Boston College picks: See picks at SportsLine
  • Louisville vs. Boston College streaming: FuboTV (Try for free)

Why Louisville can cover

The Cardinals are explosive on offense, averaging 37.4 points per game, which ranks 20th in the country. Louisville is led by quarterback Tyler Shough, who's completing 62.8% of his passes for 2,016 yards, 18 touchdowns and three interceptions. In last week's loss against Miami, Shough completed 31 of 51 passes for 342 yards and four touchdowns. 

Wide receiver Ja'Corey Brooks, an Alabama transfer, has been Shough's favorite target, hauling in 36 receptions for 679 yards and eight touchdowns. He's averaging 18.9 yards per reception and now he'll face a Boston College defense that just gave up 42 points against Virginia Tech. The Cardinals have also been tough to beat in league play, winning 13 of their previous 18 games against an ACC opponent. See which team to pick here

Why Boston College can cover

Boston College has lost two straight, but the Eagles are undefeated at home this season. Bill O'Brien's squad is averaging 158.4 rushing yards per game, led by Treshaun Ward and Turbo Richard, both of whom are averaging more than 5.0 yards per carry. Richard led the team in last week's loss against Virginia Tech, averaging 7.1 yards per carry. 

Quarterback Thomas Castellanos is the leader of this team and is coming off a productive performance against the Hokies. The junior signal caller completed 17 of 26 passes for two touchdowns and zero interceptions while also rushing for 58 yards. In addition, Boston College is 5-2 against the spread in its last seven meetings against Louisville. See which team to pick here

How to make Boston College vs. Louisville picks

The model has simulated Boston College vs. Louisville 10,000 times and the results are in. The model is leaning Under the total, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. Boston College, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.