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The Milwaukee Brewers will try to secure the series win when they battle the St. Louis Cardinals in the third of a four-game series between National League Central Division rivals on Saturday. Milwaukee earned a 6-0 win on Thursday and a 3-2 victory on Friday. Righthander Andre Pallante (4-3, 4.75 ERA) is expected to start for the Cardinals. Milwaukee is expected to counter with lefthander Jose Quintana (4-1, 2.66 ERA).

First pitch from American Family Field in Milwaukee is set for 4:10 p.m. ET. Milwaukee is -121 on the money line (risk $121 to win $100) in the latest Cardinals vs. Brewers odds from FanDuel Sportsbook, while St. Louis is a +101 underdog (risk $100 to win $101). The over/under for total runs scored is 8. SportsLine's model is calling for a big win for the Brewers in this one. 

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 12 of the 2025 MLB season on a 27-23 run on top-rated MLB money-line betting picks. Anybody following at sportsbooks and on betting apps, or new users taking advantage of the latest DraftKings promo code or Fanatics Sportsbook promo code could have seen strong returns.

Here are the model's three best bets for Cardinals vs. Brewers on Saturday (odds subject to change):

  • Brewers ML (-121)
  • Brewers run line +1.5 (+168)
  • Rhys Hoskins over 0.5 total bases (-166)

Brewers to win (-121)

Milwaukee has won three consecutive games in the series, and three of four overall. The Brewers have also played well at home, going 22-14 on their home field in 2025. The Cardinals, meanwhile, have dropped six games in a row to fall into third place in the National League Central, 1.5 games behind the Brewers. St. Louis has struggled a bit on the road, going 14-20 away from home this season. The model is confident Milwaukee can clinch the series, and has a money line probability of nearly 60%. DraftKings is one of the books with a -121 price on the Brewers, and new users can unlock even more value with a DraftKings promo code.

Brewers run line +1.5 (+171)

The model has simulated the game 10,000 times. It suggests Milwaukee will be able to cover the run line, and has the Brewers winning the game by an average score of 4.1 to 3.7, with Milwaukee covering well over 70% of the time, making it the better value. This best bet has a B rating. Milwaukee has a plus-23 run differential on the year, while St. Louis has a plus-16 run differential.

If you want even more MLB picks, SportsLine's top MLB expert, Matt Severance, is heating up. Get his best bets for Saturday, all from the expert who is 157-80 on his last 237 MLB picks (+22). 

Rhys Hoskins over 0.5 total bases (-166)

Milwaukee first baseman Rhys Hoskins is hitting .249 on the season. In 67 games, he has registered nine doubles, 10 homers and 37 RBI. In 44 career games against St. Louis, he is hitting .259 with six doubles, 11 homers and 25 RBI.

In Wednesday's 6-2 loss to the Atlanta Braves, Hoskins was 1-for-3 with a home run. The model is projecting 1.3 total bases for Hoskins, and gives this prop a five-star rating. bet365 has this line at -160, and new users can utilize the latest bet365 promo code if they want even more bang for their buck.