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The Los Angeles Dodgers (41-28) will host the San Francisco Giants (40-29) in an NL West showdown on Friday. The Dodgers have won three of their last four games, including a 5-2 win over the San Diego Padres on Wednesday. Meanwhile, the Giants had their seven-game win streak snapped on Thursday when the Colorado Rockies beat San Francisco, 8-7. Yoshinobu Yamamoto (6-4, 2.20 ERA) is on the mound for the Dodgers. Logan Webb (5-5, 2.58 ERA) is on the mound for the Giants. This is the first meeting of the season between the rivals, while L.A. went 9-4 versus San Fran last season.

First pitch from Dodger Stadium in Los Angeles is set for 10:10 p.m. ET. Los Angeles is -196 on the money line (risk $196 to win $100) in the latest Giants vs. Dodgers odds from DraftKings Sportsbook, while San Francisco is a +162 underdog (risk $100 to win $162). The over/under for total runs scored is 7.5. Before making any Giants vs. Dodgers picks, be sure to see the MLB predictions from SportsLine's proven model. You can also check out Friday's MLB home run picks.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 12 of the 2025 MLB season on a 27-23 run on top-rated MLB sides picks. It has excelled making home run prop picks, returning more than 35 units of profit over the past two months. Anybody following at sportsbooks and on betting apps could have seen strong returns, especially when paired with the latest BetMGM promo code and FanDuel promo code, just to name a few.

Here are the model's three best bets for Giants vs. Dodgers on Friday:

  • Shohei Ohtani Under 1.5 hits (-236)
  • Heliot Ramos Over 0.5 hits (-198)
  • Freddie Freeman 1+ Singles (-145)

Shohei Ohtani Under 1.5 hits (-236)

Ohtani is one of the most skilled batters in the league, ranking third in the MLB in home runs (23) and second in OPS (1.008), but is 23rd in batting average (.290). Ohtani has finished with just one hit in six straight games. In his last 10 favored games, Ohtani has hit the under seven times on his hit market. The model projects 1.0 hits for Ohtani.

If you want even more MLB picks, SportsLine's top MLB expert, Matt Severance, is heating up. Get his best bets for Wednesday, all from the expert who is 137-70 on his last 207 MLB picks (+20). 

Heliot Ramos Over 0.5 hits (-198)

Ramos leads the team in batting average (.295), OBP (.365), and hits (76). The 25-year-old has logged a base hit in five of his last eight outings. Ramos has gone over his total hits market in five of his last six games as well. In his career against the Dodgers, he has a .258 batting average with 17 hits, which includes going 3-of-5 in his last outing. 

You've now seen two best bets for Giants vs. Dodgers on Friday. Now, get picks for every single game from the model that enters Week 12 of the 2025 MLB season on a 27-23 run on top-rated MLB run-line picks.

Freddie Freeman 1+ Singles (-145)

Freeman is third in the majors in batting average (.347) with 75 hits. He's finished with a base hit in four of his last six games. He's also logged a single in three straight games. Freeman has compiled 108 total hits in his career against the Giants. FanDuel has this prop at -145.