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Quarterback Sam Darnold was efficient in his first start for the Vikings, completing 79.2% of his passes for 208 yards, two touchdowns and one interception, resulting in a 28-6 victory over the Giants. Darnold will now lead the Vikings against a stingy San Francisco defense, a unit that is familiar with his game. The former first-rounder served as San Francisco's backup quarterback last season, so the 49ers will know what to expect on Sunday. Darnold's over/under for total passing yards is 229.5 according to the latest Week 2 NFL props.

Should your Week 2 NFL prop picks include fading Darnold after the 49ers held Jets quarterback Aaron Rodgers to 167 passing yards last week? That's among the many stats you'll want to consider before locking in your Week 2 NFL player props. With sites like DraftKings, FanDuel, PrizePicks, Underdog Fantasy, Sleeper Fantasy, and more offering tons of games surrounding Week 2 NFL player props, you'll want to check out the top Week 2 player props and NFL prop predictions from the SportsLine AI PickBot

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed those NFL picks is way up.

For NFL Week 2, the AI PickBot has evaluated the NFL player prop odds and provided prop picks for every position and every available prop market for NFL betting. You can only see the AI player prop predictions for NFL Week 2 at SportsLine.

Top Week 2 QB, RB, WR player prop picks

Here's a look at some of the top Week 2 NFL prop picks from SportsLine AI: 

Quarterback: Kyler Murray, Arizona Cardinals: 215.5 passing yards 

Murray is a dynamic dual-threat quarterback but he finished with just 162 passing yards against the Buffalo Bills in Week 1. The former No. 1 overall pick doesn't throw many deep passes and averaged just 6.7 yards per completion in 2023. He led the Cardinals in rushing last week and now faces a Rams defense that held Jared Goff to 217 passing yards last week. The AI PickBot predicts that Murray throws for only 172.4 yards on average, rating the under as a 5-star play. The pick: Under 215.5 passing yards (-118)See more NFL props here.

Running Back: Aaron Jones, Minnesota Vikings: 61.5 rushing yards

Jones made an immediate impact for the Vikings after being signed this offseason from the rival Green Bay Packers. He recorded 14 carries for 94 yards and a touchdown in his debut with Minnesota, helping the Vikings secure a 28-6 victory on the road. He was the workhorse in Minnesota's backfield, and he's expected to get the Lions' share again this week against the 49ers. The AI PickBot predicts that Jones will finish with 76.8 rushing yards against San Francisco, rating the over as a 4.5-star play.  The pick: Over 61.5 rushing yards (-115). See more NFL props here.

Wide Receiver: CeeDee Lamb, Dallas Cowboys: 6.5 receptions

Lamb led the Cowboys in receptions, targets, and receiving yards last week, finishing with five catches on 10 targets for 61 yards. Dallas didn't have to throw the ball often after creating a comfortable 27-3 lead early in the second half. Lamb and the Cowboys will take on the Saints on Sunday, an offense that scored 47 points in Week 1. If this game turns into a shootout, Lamb could easily clear the posted total. The AI PickBot predicts Lamb will finish with 8.7 receptions on average, rating the over as a 5-star play. The pick: Over 6.5 receptions (-119). The pick: Over 6.5 receptions (-119). See more NFL props here.

How to make Week 2 NFL prop bets

In addition, the AI PickBot has also locked in confident Week 2 NFL prop picks involving Dak Prescott, Alvin Kamara and Stefon Diggs. It's also identified a star quarterback who sails past his total and has 12 other NFL props rated 4.5 stars or better. You must see the AI PickBot's analysis before making any NFL prop bets.

Which NFL prop bets should you target for Week 2, and which star quarterback sails past his posted total? Visit SportsLine now to see the top Week 2 NFL props, all from the SportsLine AI PickBot that nailed 1,674 top-rated picks last season.